Artikel
Limbal stem cells transplantation in chemical and thermal burns
Suche in Medline nach
Autoren
Veröffentlicht: | 18. Juni 2008 |
---|
Gliederung
Text
Background: To analyse the graft survival rate and stability of the corneal surface in patients, who underwent limbal stem cells transplantation. Three surgical techniques were applied: CLAU, lrCLAL, and KLAL transplantations.
Methods: Nonrandomized consecutive comparative case series study. For the analysis we qualified: 52 patients (52 eyes), 11 women and 41 men, aged from 11 to 78 years. Mean follow–up was 28,4, range from 8 to 72 months. Three groups: CLAU, lrCLAL and KLAL contained 16, 7 and 29 eyes respectively. Graft survival rate and clinical success of stem cells transplantation in impression cytology was evaluated. Kaplan Meier survival curve was used.
Results: Comparison of the graft survival and regularity of corneal surface between allo- and autografts showed statistically significant difference. Three years graft survival rate was 87,5% in autologous transplantation group and 47,2% in allogenic transplantation group. After six years it was 81,2% and 33,3% respectively. Restoration of corneal surface was confirmed by impression cytology.
Conclusions: Autotransplantation of the limbus in ocular surface burns shows significantly better long-term outcomes.