Artikel
Severe sinonasal epithelial dysplasia to malignancy
Suche in Medline nach
Autoren
Veröffentlicht: | 30. März 2016 |
---|
Gliederung
Text
Right sinonasal non-keratinizing squamous cell carcinoma and hard palate, middle infraorbital area, middle cranial fossa space involvement were present in an 18-year-old male patient. The patient was admitted presenting: recurrent sinusitis, right sinonasal tumor and bilateral cervical lymph node involvement. The patient presented laterocervical bilateral metastatatic masses.
Biopsy was performed and sent to the Pathology Service. Usual histological techniques were performed on the specimen. The polypoid lesion showing a connective tissue core with seromucous acini and moderate quantity of inflammatory cells (neutrophils, eosinophils, lymphocytes, histiocytes) was visible on hematoxylin eosin slides. The epithelium was pseudostratified, being composed of ciliated columnar cells and presenting areas of squamous metaplasia. A malignant tumor formed by epithelioid cells was visualised in these zones, with eosinophilic cytoplasm and vesicular nucleus containing prominent nucleolus. The cells were disposed in sheets, surrounded by fibrous connective stroma. Severe dysplasia was visible at the transition site between normal epithelium and malignant tumor, as precursor lesion. The complementary immunohistochemical tests were consistent with a non-keratinizing squamous carcinoma arising in a fibro-glandular polyp with concomitant severe epithelial dysplasia, as a starting lesion.
After extensive radiochemotherapy the patient was sign and symptom free, at 12 months no recurrence was noted.
Der Erstautor gibt keinen Interessenkonflikt an.