Artikel
Aggregation of colorectal adenoma with other malignancies in Swedish families
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Autoren
Veröffentlicht: | 10. September 2008 |
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Gliederung
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Background & Aim
Most colorectal cancers develop from benign adenomatous polyps. Risks for colorectal adenoma for individuals with a family history of extracolorectal cancer have not been studied.
Materials and Methods
Familial relative risks (RRs) for colorectal adenoma were estimated based on the offspring generation of the Swedish Family-Cancer Database, which includes over 11.5 million individuals. RRs were calculated using Poisson regression.
Results
The risk of colorectal adenoma was increased among first degree relatives of patients with colorectal cancer (RR 2.71; 95% confidence interval (CI) 2.46-3.00). Family history of malignancies other than colorectal cancer was also associated with colorectal adenoma. We found an increased risk of colon adenoma for the offspring of individuals affected by stomach, lung, prostate and liver cancers and leukaemia; the relative risk for acute lymphoblastic leukaemia was 6.31 (95% CI 2.63-15.20). The risk of colon adenoma was increased among siblings of patients with endometrial and prostate cancers and with multiple myeloma. The offspring of patients with pancreatic and endometrial cancers and melanoma, and the siblings of patients with pancreatic, cervical, skin and nervous system cancers and multiple myeloma were at an increased risk of rectal adenoma.
Conclusions
Our results suggest that colorectal adenoma shares a genetic etiology with cancer even at extracolorectal sites. Some of the observed associations are probably related to known colorectal cancer syndromes. However, some cancer types that cluster in families affected by colorectal adenoma cannot be attributed to known cancer syndromes, such as lung, prostate and skin cancers, acute leukaemias and multiple myeloma.
References
- 1.
- Hiripi E, Lorenzo Bermejo J, Sundquist J, Hemminki K. Association of colorectal adenoma with other malignancies in Swedish families. Br J Cancer. 2008;98(5):997-1000.