Artikel
Breast cancer and exercise
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Veröffentlicht: | 24. Oktober 2011 |
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Gliederung
Text
Objective: The aim of this study was to define the correlation between breast cancer and physical exercise and the mechanism for the prevention of breast cancer by physical exercise.
Material/Methods: The material emanates from a review of the international bibliography and from our own study in our Laboratory in Thessaloniki, Hellas.
Results: Sufficient evidence has accumulated to warrant an analysis of the relationship between exercise and breast cancer. Recent epidemiological studies confirm an inverse relationship between exercise and breast cancer, with stronger associations appearing for occupational activity than for leisure time or nonoccupational activity. Several plausible hypothesized biological mechanisms exist for the association between physical activity and breast cancer, including changes in endogenous sexual and metabolic hormone levels and growth factors, decreased obesity and central adiposity and possibly changes in immune function. Central adiposity has been particularly implicated in promoting metabolic conditions amenable to carcinogenesis. Exercising four or more hours a week may decrease hormone levels and help lower breast cancer risk.
Conclusion: The mechanisms are not well defined; several lines of evidence support the inclusion of low-to-moderate exercise as a preventive strategy for breast cancer.
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