Artikel
Association of hepatitis E virus and cryoglobulinemia
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Veröffentlicht: | 1. September 2015 |
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Gliederung
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Introduction: Several extrahepatic manifestations have been observed in the context of acute or chronic hepatitis E virus infections. Recently a case indicated an association between HEV infection and cryoglobulinemia [1], but this observation still needs to be confirmed and clarified.
Methods: Stored serum samples of 68 German patients with cryogluobulinemia were retrospectively tested for anti HEV IgG (Wantai assay). Seroprevalence rates were compared in patients with essential cryoglobulinemia (n=33) and in patients with cryoglobulinemia secondary to various underlying conditions (n=35) using chi square test.
Results: Within the group of patients with essential cryoglobulinemia 46% (n=15) tested positive for anti HEV IgG, while in the group of patients with different underlying conditions 23% (n=8) tested positive (p=0.043).
Conclusion: Patients with essential cryoglobulinemia tested positive more frequently for anti HEV than patients with secondary cryoglobulinemia due to well defined causes. This indicates that development of cryoglobulinemia of unknown origin is a relevant extrahepatic manifestation of hepatitis E.
References
- 1.
- Pischke S, Behrendt P, Manns MP, Wedemeyer H. HEV-associated cryoglobulinaemia and extrahepatic manifestations of hepatitis E. Lancet Infect Dis. 2014 Aug;14(8):678-9. DOI: 10.1016/S1473-3099(14)70823-0