Artikel
A novel dynamic model for experimental spinal cord compression
Ein neues dynamisches Modell zur experimentellen Rückenmarkskompression
Suche in Medline nach
Autoren
Veröffentlicht: | 23. April 2004 |
---|
Gliederung
Text
Objective
To present a novel dynamic model for experimental spinal cord compression.
Methods
The spine is exposed in the midthoracic level via a dorsal approach. On each side of one vertebral lamina, a small hole is countersunk caudal of the articular process. A silicon band is passed through these holes resulting in formation of a loop. The spinal dura is exposed performing an interlaminar approach and by gently pulling at the ends of the band the loop is brought in contact with the dura. The ends of the band are passed through rubber tubes on both sides and a hemoclip is attached to the band. Thus the loop is fixed in its position encircling 270° of the circumference of the spinal cord. Subsequently the loop is gradually tightened by pulling at the ends of the bands and fixing it again in its new position. In doing so the spinal cord is increasingly compressed in a dynamic manner. Decompression of the spinal cord is easily achieved by cutting one band and removing the whole device.
Results
This new model was established in 30 white rabbits, and it was feasible to create reproducible progressive neurological deficits in all animals. The compressive effect of the loop is impressively presented using MRI. The severity of the paresis depended on the degree and duration of compression. Decompressing the spinal cord, the neurological deficits were reversible in the majority of animals. In those animals who did not recover subsequent MRI revealed the occurrence of chronic myelopathy.
Conclusions
This novel model features reproducibility of paresis and neurological recovery. Since it is a dynamic model, and rate and degree of compression can be chosen arbitrarily, it can be used for acute, subacute, and chronic spinal cord compression in equal measure.